منابع مشابه
Renal tubular drug transporters.
The kidney plays an important role in the elimination of numerous hydrophilic xenobiotics, including drugs, toxins, and endogenous compounds. It has developed high-capacity transport systems to prevent urinary loss of filtered nutrients, as well as electrolytes, and simultaneously to facilitate tubular secretion of a wide range of organic ions. Transport systems for organic anions and cations a...
متن کاملRenal drug transporters and nephrotoxicity
Among drug-induced renal failure, direct renal tubular toxicity, typically described as toxic acute tubular necrosis, is often associated with increased cellular uptake of nephrotoxic compounds. Drug transporters in tubular cells are the first fundamental stage in the development of the nephrotoxic process. Several examples can be given of organic substances that are nephrotoxic only after bein...
متن کاملRenal Tubular Sodium Transporters and Genetic Basis of Hypertension
Renal regulation of total body sodium (Na) plays an important role in volume-dependent blood pressure control through different molecular mechanisms. Gain of renal tubular Na transporter function in different segments is primarily responsible for essential and monogenic forms of hypertension. In this review, we summarize the physiological regulation of the major renal tubular Na transporters an...
متن کاملRenal drug transporters and their significance in drug–drug interactions
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules in the kidney. Tubular secretion is characterized by high clearance capacities, broad substrate specificities, and distinct charge selectivity...
متن کاملEffects of chronic renal failure on liver drug transporters.
Chronic renal failure (CRF) is associated with a decrease in liver drug metabolism, particularly mediated by the cytochrome P450. CRF also impedes intestinal drug transporters [mainly P-glycoprotein (P-gp) and multidrug resistance protein (MRP)]. However, very few studies have evaluated the effects of CRF on liver drug transport. The present study aimed to investigate the repercussions of CRF o...
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ژورنال
عنوان ژورنال: Nephron Physiology
سال: 2006
ISSN: 1660-2137
DOI: 10.1159/000092212